The interruption of disease outbreaks through vaccination can yield a significant return on investment. – VoICE
Key Concept

Key Evidence: Considering both the direct and indirect costs, researchers in the Netherlands estimated that the preventative immunization of Dutch healthcare workers (HCW) against pertussis (to reduce exposure and transmission contributing to outbreaks) results in a return on investment of 4 Euros to every 1 euro invested. This projection assumes an outbreak of pertussis once every 10 years.

Tariq, L., Mangen, M. J., Hövels, A., 2015. Modelling the return on investment of preventatively vaccinating healthcare workers against pertussis. BMC Infectious Disease. 15(1).
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Key Evidence: In a study of a 2003 outbreak of pertussis in the U.S., including 17 cases among healthcare workers, researchers estimated that vaccinating healthcare workers would result in a 2.4-fold return on investment for hospitals.

Calugar A, Ortega-Sanchez I, Tiwari T et al. 2006. Nosocomial pertussis: Costs of an outbreak and benefits of vaccinating health care workers. CID. 42.
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