VoICE Immunization Evidence: Antimicrobial Resistance

Key Idea

Reductions in the number of days that patients received antibiotic therapy have been documented among day-care attendees in Israel who received the 9-valent conjugate vaccine. Children who received vaccine had 10% fewer days of antibiotic usage for upper respiratory tract infections, 47% fewer days of antibiotic usage for lower respiratory tract infections, and 20% fewer days of antibiotic usage for otitis media (ear infections) as compared to children who did not receive PCV.

Dagan, R., Sikuler-Cohen, M., Zamir, O., et al 2001. Effect of a conjugate pneumococcal vaccine on the occurrence of respiratory infections and antibiotic use in day-care center attendees. Pediatric Infectious Disease Journal. 20(10):951-8.

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In a study of nearly 40,000 recipients of PCV7 and control subjects in northern California, there was a 5.4% reduction in the number of antibiotic prescriptions and a 12.6% reduction in the use of “second-line antibiotics” among children who received the pneumococcal conjugate vaccine. Between the time the first dose was administered and the age of 3.5 years, use of the vaccine prevented 35 antibiotic prescriptions per 100 fully vaccinated children.

Fireman, B., Black, S.B., Shinefield, H.R., et al 2003. Impact of pneumococcal conjugate vaccine on otitis media. Pediatric Infectious Disease Journal. 22(1):10-6.

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