VoICE Immunization Evidence: Cost effectiveness

Key Idea

A multi-site study of cholera vaccination programs found that the vaccine was cost-effective in school- and community-based vaccination programs for children in India, Mozambique and Indonesia.

Jeuland, M., Cook, J., Poulos, C., et al 2009. Cost-effectiveness of new-generation oral cholera vaccines: A multisite analysis. Value Health. 12:899–908.

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PCV7 use in Argentina resulted in an estimated cost of US$5599 per life year gained and the purchase of the 4 doses of vaccine for the entire cohort at a cost of US$ 26.5 dose would require an investment of US$ 73,823,806.00.

Giglio, N.D., Cane, A.D., Micone, P., et al 2010. Cost-effectiveness of the CRM-based 7-valent pneumococcal conjugated vaccine (PCV7) in Argentina. Vaccine. 28:2302–2310.

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Assuming 90% coverage, a program in The Gambia using a 9-valent PCV (PCV9) would prevent approximately 630 hospitalizations, 40 deaths, and 1000 DALYs, over the first 5 years of life of a birth cohort. The estimated cost would be $670 per DALY averted in The Gambia.

Kim, S., Lee, G. and Goldie, S. 2010. Economic evaluation of pneumococcal conjugate vaccination in The Gambia. BMC Infectious Diseases. 10:260.

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A study on the cost-effectiveness of universal vaccination in children found that at 95% vaccine coverage, the Hepatitis A immunization program in Argentina can reduce over 350,000 hepatitis A infections per year and 428 deaths. Benefits are observed when coverage is as low as 70% with over 290,000 prevented infections. In terms of cost, the program would save almost $24,000 annually at 95% coverage.

Lopez, E., Debbag, R., Coudeville, L., et al 2007. The cost-effectiveness of universal vaccination of children against hepatitis A in Argentina: results of a dynamic health-economic analysis. Journal of Gastroenterology. 42:152–160.

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