Publication

A small jab – a big effect: Nonspecific immunomodulation by vaccines

Authored by:

Benn, C. S., Netea, M. G., Selin, L. K., & Aaby, P.

Full Citation:

Benn, C. S., Netea, M. G., Selin, L. K., & Aaby, P. 2013. A small jab – a big effect: Nonspecific immunomodulation by vaccines. Trends in Immunology. 34(9).

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Additional key concepts from this publication:

Administration of vaccines can also decrease childhood deaths from other causes, above and beyond the expected direct impact of the vaccine.

Key Evidence: This 2013 review summarizes data from several randomized trials in which measles and tuberculosis vaccines were associated with a substantial reduction in overall child mortality, which cannot be solely explained by prevention of the target disease. These studies suggest that in addition to disease-specific effects, some live vaccines may also provide “nonspecific effects” that enhance the immune system’s ability to protect against additional pathogens.