Publication

Early declines in vaccine type pneumococcal carriage in children less than 5 years old after introduction of 10-valent pneumococcal conjugate vaccine in Mozambique

Authored by:

Sigauque B, Moiane B, Massora S et al.

Full Citation:

Sigauque B, Moiane B, Massora S et al. 2018. Early declines in vaccine type pneumococcal carriage in children less than 5 years old after introduction of 10-valent pneumococcal conjugate vaccine in Mozambique. Pediatric Infectious Disease Journal . 37(10).

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Additional key concepts from this publication:

Vaccination can help improve the health equity of those who are HIV positive.

Key Evidence: Within two years of the introduction of PCV10 in Mozambique, the percent of vaccinated children under five years of age with nasopharyngeal carriage of vaccine strains, declined equally in HIV-infected as in HIV-uninfected children. The vaccine-type carriage rates among both HIV-infected and uninfected vaccinated children after the vaccine was introduced were similar.

From the VoICE Editors: Pneumococcal nasopharyngeal carriage can be a precursor of invasive pneumococcal disease.

Immunization can help protect unimmunized children, adults and the elderly through herd effects.

Key Evidence: Two years after the introduction of 10-strain pneumococcal conjugate vaccine (PCV-10) in Mozambique, the percent of unvaccinated children under five years of age who carried pneumococcal strains in the vaccine declined 30% among HIV-infected children, while no significant decline in unvaccinated HIV-negative children was seen.