Publication

Effectiveness of maternal pertussis vaccination in preventing infection and disease in infants: the NSW Public Health Network case-control study

Authored by:

Saul N, Wang, Bag S et al.

Full Citation:

Saul N, Wang, Bag S et al. 2018. Effectiveness of maternal pertussis vaccination in preventing infection and disease in infants: the NSW Public Health Network case-control study. Vaccine. 36(14).

View Publication

Additional key concepts from this publication:

Maternal immunization offers an opportunity to protect the mother and fetus, but also passes this protection on to the infant after birth.

Key Evidence: A case-control study in the state of New South Wales, Australia estimated that vaccination of pregnant women with the dTpa vaccine at 28-32 weeks of pregnancy was highly effective in preventing severe pertussis in infants less than 6 months of age — with a vaccine efficacy rate of 94% against pertussis hospitalizations — and 69% effective in preventing the disease of any severity in infants less than 3 months old.

From the VoICE Editors: Note: The formulation used in this study is abbreviated dTpa.

Maternal immunization offers an opportunity to protect the mother and fetus, but also passes this protection on to the infant after birth.

Key Evidence: A study in Australia estimated that adding dTpa vaccination for pregnant women to the current pertussis immunization program for children would prevent an additional 8,800 symptomatic pertussis cases (mostly unreported) and 146 hospitalizations each year in all ages, including infants and their mothers, as well as one death every 22 months. The study found maternal pertussis vaccination to be cost-effective.

From the VoICE Editors: Note: The formulation used in this study is abbreviated dTpa.

Immunization can decrease hospital admissions, thus alleviating pressure on overburdened health systems.

From the VoICE Editors: Note: The formulation used in this study is abbreviated dTpa.

Vaccines are among the most cost-effective health interventions available.

From the VoICE Editors: Note: The formulation used in this study is abbreviated dTpa.