Publication

Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials

Authored by:

Omer, S. B., Clark, D. R., Madhi, S. A., Tapia, M. D., Nunes, M. C., Cutland, C. L., ... & Steinhoff, M. C.

Full Citation:

Omer, S. B., Clark, D. R., Madhi, S. A., Tapia, M. D., Nunes, M. C., Cutland, C. L., ... & Steinhoff, M. C. 2020. Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials. The Lancet Respiratory Medicine. 8(6).

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Additional key concepts from this publication:

Maternal immunization offers an opportunity to protect the mother and fetus, but also passes this protection on to the infant after birth.

A pooled analysis of three randomized controlled trials conducted in Nepal, Mali, and South Africa between 2011 and 2014 found that immunization during pregnancy provided protection against influenza to young infants from birth through 4 months of age. Protection against infant influenza was greatest in the first 2 months of life, with 56% efficacy, and the pooled efficacy of maternal vaccination to prevent infant laboratory-confirmed influenza up to 6 months of age was 35%.