VoICE Immunization Evidence
Estimating the herd immunity effect of rotavirus vaccine
From the VoICE Editors
The herd effect represents the additional reduction in diarrhea hospitalizations observed in studies beyond the expected reduction given vaccine efficacy and reported coverage rates.
A meta-analysis conducted of data from studies measuring the impact of rotavirus vaccine (RVV) on severe gastroenteritis morbidity and mortality, reported a median herd immunity effect for severe rotavirus gastroenteritis in children less than one year of age of 22% (US and El Salvador). In studies in Latin America reporting an all-cause gastroenteritis benefit the median herd effect for severe gastroenteritis was 24.9%.