Publication

Infections among long‐term survivors of childhood and adolescent cancer: A report from the Childhood Cancer Survivor Study

Authored by:

Perkins, J.L., Chen, Y., Harris, A., et al.

Full Citation:

Perkins, J.L., Chen, Y., Harris, A., et al. 2014. Infections among long‐term survivors of childhood and adolescent cancer: A report from the Childhood Cancer Survivor Study. Cancer. 120(16).

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Additional key concepts from this publication:

Immunosuppressive treatments can increase the risk and severity of a range of potentially vaccine-preventable infections.

Key Evidence: In survivors of pediatric and young adult cancers in the US, the risk of mortality from infectious complications is 4 times higher than in their cancer-naïve siblings. Within the first five years after cancer diagnosis, the risk of some vaccine-preventable infections such as pneumonia and hepatitis is more than 9-fold and 6-fold higher, respectively. More than 5 years after cancer diagnosis, the risk of these two infections remains high at 3.7 and 2.5 times higher than siblings.