Publication

Predicting the impact of typhoid conjugate vaccines on antimicrobial resistance

Authored by:

Kaufhold S, Yaesoubi R, Pitzer VE

Full Citation:

Kaufhold S, Yaesoubi R, Pitzer VE 2019. Predicting the impact of typhoid conjugate vaccines on antimicrobial resistance. Clinical Infectious Diseases. 68(2).

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Additional key concepts from this publication:

The use of vaccines is a critical step in controlling the occurrence of antibiotic-resistant infections.

Key Evidence: A study of the impact of typhoid conjugate vaccines in a hypothetical endemic population predicts that the number of antibiotic-resistant typhoid cases will decrease sharply if at least 80% of infants are vaccinated. However, the percent of cases that are resistant is not expected to change with vaccination, thus the disease will have to be nearly eliminated to get rid of all antibiotic resistant typhoid.

The use of vaccines is a critical step in controlling the occurrence of antibiotic-resistant infections.

Key Evidence: According to a study in a hypothetical endemic population, vaccination using typhoid conjugate vaccine will reverse the current increase in the percent of chronic carriers of the disease who are antibiotic resistant, if at least 50% of the target population is vaccinated. This would deplete an important “reservoir” of antibiotic resistant typhoid.