Publication

Systematic review of the non-specific effects of BCG, DTP and measles-containing vaccines

Authored by:

World Health Organization, Strategic Advisory Group of Experts

Full Citation:

World Health Organization, Strategic Advisory Group of Experts 2014. Systematic review of the non-specific effects of BCG, DTP and measles-containing vaccines.

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Additional key concepts from this publication:

In some cases, girls may reap a greater benefit from some vaccinations than boys.

Key Evidence: Across multiple studies reviewed, the effect of measles vaccine appears to be more beneficial to girls combating all-cause mortality when differences between vaccine effect in boys and girls was assessed.

Administration of vaccines can also decrease childhood deaths from other causes, above and beyond the expected direct impact of the vaccine.

Key Evidence: In a 2014 review of the non-specific effects of measles vaccines, among others, the WHO Strategic Advisory Group of Experts indicated that some studies of measles vaccine were suggestive (but not conclusive) of a beneficial effect of measles vaccine on overall mortality beyond the expected direct effect of the vaccine against measles. In particular, randomized control trials of children in Guinea- Bissau which looked at mortality up to the age of 9 months showed a low number of deaths post administration of the 3 doses of the measles vaccine over the study follow up period. Another trial in Nigeria also showed similar results.