"KEY IDEAS",REFERENCE,"KEY RESULTS",ABSTRACT,YEAR,VPD,LOCATION "The greatest cost savings to be had by introducing new vaccines and increasing immunization coverage would occur in countries and regions with high disease burden and/or large populations","""Stack, M. L., Ozawa, S., Bishai, D. M., et al. 2011. Estimated Economic Benefits During The ‘Decade Of Vaccines’ Include Treatment Savings, Gains In Labor Productivity. Health Affairs. 30(6)""","In a modeled analysis of the economic impact of vaccine use in the world’s 72 poorest countries, for countries included in the analyses from the African region, scaling up coverage of the Rotavirus (RVV) vaccine to 90% was projected to result in more than $900 million in treatment costs averted. ",https://doi.org/10.1377/hlthaff.2011.0382,2011,,"Global, Gavi-eligible country" "The interruption of disease outbreaks through vaccination can yield a significant return on investment.","""Tariq, L., Mangen, M. J., Hövels, A., 2015. Modelling the return on investment of preventatively vaccinating healthcare workers against pertussis. BMC Infectious Disease. 15(1), 75""","Considering both the direct and indirect costs, researchers in the Netherlands estimated that the preventative immunization of Dutch healthcare workers (HCW) against pertussis (to reduce exposure and transmission contributing to outbreaks) results in a return on investment of 4 Euros to every 1 euro invested. This projection assumes an outbreak of pertussis once every 10 years. ",https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-0800-8,2015,Pertussis,"European Region, NETHERLANDS" "Vaccination programs such as those for Rotavirus have shown a significant short-term return on investment.","""Atkins, K.E., Carroll, S., et al. 2012. The cost-effectiveness of pentavalent rotavirus vaccination in England and Wales.. Vaccine. 30(48), 6766""","In a UK cost-effectiveness analysis, which takes into account herd effect, the budget impact analysis demonstrated that the introduction of a rotavirus vaccine (RVV) program could pay back between 58-96% of the cost outlay for the program within the first 4 years. ",https://www.ncbi.nlm.nih.gov/pubmed/23000223,2012,"Diarrhea, Rotavirus","European Region, ENGLAND, WALES" "Vaccination programs such as those for Rotavirus have shown a significant short-term return on investment.","""Carroll, S., García Rojas, A. J., et al. 2015. Vaccination: short- to long-term benefits from investment. Market Access & Health Policy. 3: 27279""","In an economic evaluation of vaccination against rotavirus conducted in Italy, it was shown that as early as the second year after rotavirus vaccine introduction, the vaccine cost would be more than offset by savings from prevention of disease cases and hospitalizations. ",http://dx.doi.org/10.3402/jmahp.v3.27279,2015,, "Investing in immunization programs in the world’s poorest countries yields a return significantly greater than the initial investment.","""Ozawa, S., Portnoy, A., Grewal, S., et al 2016. Return on investment from childhood immunization in low- and middle-income countries, 2011-2020. Health Affairs. 35(2)""","A recent study estimated that, during the decade from 2011-2020, every $1 invested in immunization programs in the world’s 73 poorest countries would yield a $16 return on investment. Using an approach accounting for additional societal benefits of vaccination (the “full income approach”, which quantifies the value that people place on living longer and healthier lives), researchers estimated the return could be as high as $44 per $1 invested. ",https://www.ncbi.nlm.nih.gov/pubmed/?term=26858370,2016,"Diarrhea, Haemophilus lnfluenzae type b (Hib), Hepatitis A & B, Human papillomavirus (HPV), Japanese encephalitis, Measles, Meningitis, Meningococcal disease / MenACWY, Pneumococcal disease / PCV / PPSV, Pneumonia, Rotavirus, Yellow fever","Global, Gavi-eligible country" "Investing in immunization programs in the world’s poorest countries yields a return significantly greater than the initial investment.","""Bloom, D.E., Canning, D., and Weston, M. 2005. The value of vaccination. World Economics. 6(3):15-39""","Vaccination of children in the Philippines against 6 diseases was found to significantly increase IQ and language scores (compared to children receiving no vaccinations) and was estimated to have a 21% rate of return. ",http://vaccinews.net/downloads/David%20E%20Bloom%20-%20The%20value%20of%20vaccination.pdf,2005,"Diphtheria, Measles, Pertussis, Polio / OPV / IPV, Tuberculosis / BCG, Tetanus","Western Pacific Region, PHILIPPINES"