VoICE Immunization Evidence: Long term disability

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Long Term Disability

The Long term disability section contains proof points and evidence related to the abnormal health conditions or diseases related to vaccine preventable diseases. These diseases can be costly to treat and carry long-term consequences for learning, physical functions and future productivity. Visit the Economics, Education and Health Equity sections for more information on some of these consequences.

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2 Key Ideas, 4 Sources
Key Idea

Those who experienced more frequent or longer episodes of diarrhea as an infant were more likely to have metabolic syndrome as adults. A longitudinal study in Guatemala found that diarrhea episodes in early infancy are associated with chronic health issues later in life. Each 1% increase in diarrhea burden in children 0-6 months was associated with a 3% increased prevalence in high blood pressure in adulthood. Similarly, a 1% increase in diarrhea burden in older infants 6-12 months was associated with a 4% increased prevalence in elevated waist circumference in adulthood.

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Key Idea

In a study of data from England & Wales, Denmark and the US, it was shown that measles infection suppresses the immune system for up to 3 years after infection, increasing the risk of death due to other childhood infections during that time. This means that prevention of measles significantly impacts overall health during critical childhood years.

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In Gambia, 58% of children who survived a bout of pneumococcal meningitis “had clinical sequelae; half of them had major disability preventing normal adaptation to social life” (mental retardation, hearing loss, motor abnormalities, seizures).

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In a systematic literature review of studies in Africa, the authors conclude: “Bacterial meningitis in Africa is associated with high mortality and risk of neuropsychological sequelae. Pneumococcal and Hib meningitis kill approximately one third of affected children and cause clinically evident sequelae in a quarter of survivors prior to hospital discharge. The three leading causes of bacterial meningitis are vaccine preventable, and routine use of conjugate vaccines could provide substantial health and economic benefits through the prevention of childhood meningitis cases, deaths, and disability.”

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A woman carrying vaccines

Search for immunization evidence

The VoICE tool allows you to search for research studies and published evidence based on a topic, location, and disease or vaccine.

Search VoICE