Two years after the introduction of 10-strain pneumococcal conjugate vaccine (PCV-10) in Kenya, the percent of HIV-positive adults who carried pneumococcal bacteria declined significantly (from 43% to 28%), but did not decline in HIV-negative adults. However, the reduction in carriage of pneumococcal strains that are in PCV10 declined significantly in both HIV-positive and HIV-negative adults. This reduction was still four times higher in HI- positive vs. HIV-negative adults (2.8% vs. 0.7%), indicating that HIV positive adults continue to be at considerably higher risk of invasive pneumococcal disease than HIV-uninfected adults.
Nasopharyngeal carriage is an indicator of the risk for invasive pneumococcal disease and pneumonia
Full Citation:
Kobayashi M, Bigogo G, Kim L et al.. 2020. Impact of 10-valent pneumococcal conjugate vaccine introduction on pneumococcal carriage and antibiotic susceptibility patterns among children aged <5 years and adults with HIV infection, Kenya 2009-2013. Clinical Infectious Diseases. 70(5).
Title of Article: Impact of 10-valent pneumococcal conjugate vaccine introduction on pneumococcal carriage and antibiotic susceptibility patterns among children aged <5 years and adults with HIV infection, Kenya 2009-2013
Author(s): Kobayashi M, Bigogo G, Kim L et al.
Publication Year: 2020
Publication Name: Clinical Infectious Diseases
Publication Volume: 70(5)
Publication Source URL: https://pubmed.ncbi.nlm.nih.gov/30959526/
DOI (Digital Object Identifier): 10.1093/cid/ciz285