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Vaccination can decrease childhood deaths from other causes (non-specific effects) above and beyond the expected direct impact of the vaccine

In a 2014 review of the non-specific effects of measles vaccines, among others, the WHO Strategic Advisory Group of Experts indicated that some studies of measles vaccine were suggestive (but not conclusive) of a beneficial effect of measles vaccine on overall mortality beyond the expected direct effect of the vaccine against measles. In particular, randomized control trials of children in Guinea- Bissau which looked at mortality up to the age of 9 months showed a low number of deaths post administration of the 3 doses of the measles vaccine over the study follow up period. Another trial in Nigeria also showed similar results.

Full Citation:
World Health Organization, Strategic Advisory Group of Experts (SAGE) non-specific effects of vaccines Working Group. 2014. Systematic review of the non-specific effects of BCG, DTP and measles-containing vaccines. Background paper for SAGE discussions. .

Title of Article: Systematic review of the non-specific effects of BCG, DTP and measles-containing vaccines

Author(s): World Health Organization, Strategic Advisory Group of Experts (SAGE) non-specific effects of vaccines Working Group

Publication Year: 2014

Publication Name: Background paper for SAGE discussions

Publication Volume:

Topics: Health

Disease Vaccines: Measles

Countries: Global