The Knowledge Hub

What is the Knowledge Hub?

Explore the VoICE Knowledge Hub—a searchable database featuring the latest peer-reviewed research on immunization benefits, especially in low- and middle-income countries. Browse the Knowledge Hub using a variety of different filters to find vaccine evidence based on country, region, topic, or disease. Click on a tag to find more evidence on a specific area, such as the return on investment of vaccines or impacts of infectious disease outbreaks.


Diseases & Vaccines


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Influenza vaccination for healthcare workers reduced sick days during flu seasons

Healthcare workers who received an influenza vaccine missed fewer days of work compared to non-vaccinated peers (1.74 vs 2.71 days/person). The study took place at a large Italian hospital that employed approximately 5,300 healthcare workers. The researchers examined a severe influenza season (2017/2018) as well as three moderate flu seasons (2010-2013).

Gianino MM, Kakaa O, Politano G et al.. 2021. Severe and moderate seasonal influenza epidemics among Italian healthcare workers: A comparison of the excess of absenteeism. Influenza and Other Respiratory Viruses. 15(1).

Influenza vaccination reduces absenteeism among healthcare workers

In a retrospective cohort study among healthcare workers (HCWs) of an Italian academic healthcare trust during the 2017–2018 influenza season, non-vaccinated HCWs lost 2.47/100 person-days of work compared to 1.92/100 person-days of work among vaccinated HCWs (p < 0.001). This adds further evidence that absenteeism among HCWs is negatively correlated with influenza vaccination.

Antinolfi F, Battistella C, Brunelli L et al.. 2020. Absences from work among healthcare workers: are they related to influenza shot adherence?. BMC Health Services Research. 20(1).

Screening tests in Italy found high rates of infectious diseases in newly-arrived migrants, emphasizing the need for universal screening

Screening tests given to more than 300 newly-arrived economic migrants and asylum seekers in Italy — the majority from sub-Saharan Africa — found high rates of chronic hepatitis B infection and latent and active tuberculosis (with 8% having signs of current infection or active TB). These findings underscore the important of universal screening for infectious diseases for all newly-arrived migrants.

Cuomo G, Franconi I, Riva N et al.. 2019. Migration and health: a retrospective study about the prevalence of HBP, HIV, HCV, tuberculosis and syphilis infections amongst newly arrived migrants screened at the Infectious Diseases Unit of Modena, Italy. Journal of Infection and Public Health. 12(2).

Vaccination programs, such as those for rotavirus, have shown short-term return on investment

In an economic evaluation of vaccination against rotavirus conducted in Italy, it was shown that as early as the second year after rotavirus vaccine introduction, the vaccine cost would be more than offset by savings from prevention of disease cases and hospitalizations.

Carroll, S., García Rojas, A. J., et al.. 2015. Vaccination: short- to long-term benefits from investment. Market Access & Health Policy. 3(1).