What is the Knowledge Hub?
Explore the VoICE Knowledge Hub—a searchable database featuring the latest peer-reviewed research on immunization benefits, especially in low- and middle-income countries. Browse the Knowledge Hub using a variety of different filters to find vaccine evidence based on country, region, topic, or disease. Click on a tag to find more evidence on a specific area, such as the return on investment of vaccines or impacts of infectious disease outbreaks.
Search
Diseases & Vaccines
Country
WHO Regions
Topics
Immunization Terms
Immunization can prevent long-term effects of meningococcal disease, such as hearing loss and psychological problems
A systematic literature review of studies of the long-term effects of invasive meningococcal disease in high-income countries found that children who survived the disease had a greater incidence of hearing loss and psychological problems, including attention-deficit/hyperactivity disorder (ADHD) than control groups or the general population. In addition, they had increased odds of death – one study showed more than a 25% greater mortality rate in this population than did the general public up to 30 years after having the disease.
Strifler L, Morris SK, Dang V et al.. 2016. The health burden of invasive meningococcal disease: a systematic review. Journal of the Pediatric Infectious Diseases Society. 5(4).
Immunization reduces the risk of invasive pneumococcal disease, but those on immunosuppressants still have higher chances
Even though the incidence of invasive pneumococcal disease declined in all groups, including individuals on immunosuppressive drugs, following the introduction of pneumococcal conjugate vaccines for infants in Norway, people on chemotherapy were still 20 times more likely to get IPD than individuals not on any immunosuppressants, while individuals on long-term corticosteroids or other immunosuppressive drugs were around 6 times more likely to get the disease.
Steens A, Winje BA, White RA et al.. 2019. Indirect effects of pneumococcal childhood vaccination in individuals treated with immunosuppressive drugs in ambulatory care: a case-cohort study. Clinical Infectious Diseases. 68(8).
Childhood vaccination with PCVs reduces the incidence of invasive pneumococcal disease and benefits the whole population
A large study in Norway found that the overall incidence of invasive pneumococcal disease (IPD) declined significantly in individuals on immunosuppressive drugs following the introduction of PCVs for infants — and most significantly in people undergoing chemotherapy. These findings underscore the benefits that childhood vaccination with PCVs affords the entire population.
Steens A, Winje BA, White RA et al.. 2019. Indirect effects of pneumococcal childhood vaccination in individuals treated with immunosuppressive drugs in ambulatory care: a case-cohort study. Clinical Infectious Diseases. 68(8).
Rotavirus hospitalizations cause significant economic burden due to work and school absenteeism
Children hospitalized with rotavirus in Norway were absent from daycare for 6.3 days, on average, and 73% of their parents missed work — for a mean of almost 6 days. These data, which can be used in economic evaluations of rotavirus vaccination, show that work absenteeism resulting from having a child hospitalized with rotavirus poses a considerable economic burden on society.
Edwards CH, Bekkewold T, Flem E.. 2017. Lost workdays and healthcare use before and after hospital visits due to rotavirus and other gastroenteritis among young children in Norway. Vaccine. 35(28).