The Knowledge Hub

What is the Knowledge Hub?

Explore the VoICE Knowledge Hub—a searchable database featuring the latest peer-reviewed research on immunization benefits, especially in low- and middle-income countries. Browse the Knowledge Hub using a variety of different filters to find vaccine evidence based on country, region, topic, or disease. Click on a tag to find more evidence on a specific area, such as the return on investment of vaccines or impacts of infectious disease outbreaks.


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Immunization campaigns provide more equitable access to childhood vaccinations compared to maternal health services

An analysis of survey data in Latin America and Caribbean countries found that DPT3 coverage rates among indigenous children were significantly lower than in children of European or mixed ethnicity in three out of 14 countries, while significant inequities between these groups in coverage of maternal health services, such as antenatal care and delivery by a skilled birth attendant, existed in most of the countries. The greater equity in access to childhood vaccination by ethnic group may be because vaccinations are often delivered in the communities through immunization campaigns, whereas maternal health services require accessing health facilities, which may incur user fees and transportation costs.

Mesenburg MA, Restrepo-Mendez MC, Amigo H et al.. 2018. Ethnic group inequalities in coverage with reproductive, maternal and child health interventions: cross-sectional analyses of national surveys in 16 Latin America and Caribbean countries. Lancet Global Health. 6(8).

Immunization with rotavirus vaccine may also reduce severe gastroenteritis cases in unimmunized children through herd immunity

A meta-analysis of studies measuring the impact of rotavirus vaccine (RVV) on severe gastroenteritis morbidity and mortality, found a 22% herd immunity effect for severe rotavirus gastroenteritis in children less than one year of age in US and El Salvador.  In Latin America, severe gastroenteritis due to any cause was reduced by 25%.

Pollard, S.L., Malpica-Llanos, T., Friberg, I.K., et al.. 2015. Estimating the herd immunity effect of rotavirus vaccine. Vaccine. 33(32).