The Knowledge Hub

What is the Knowledge Hub?

Explore the VoICE Knowledge Hub—a searchable database featuring the latest peer-reviewed research on immunization benefits, especially in low- and middle-income countries. Browse the Knowledge Hub using a variety of different filters to find vaccine evidence based on country, region, topic, or disease. Click on a tag to find more evidence on a specific area, such as the return on investment of vaccines or impacts of infectious disease outbreaks.


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Dengue illness is costly for low-income families, but immunization can help reduce the economic burden

In a standardized survey of the costs of dengue illness in three highly endemic countries, the economic burden of dengue was greatest on Vietnamese and Colombian low-income families, whose total costs, including lost wages, outpatient and inpatient cases combined, average 36-45% of their monthly household income. In Thailand, although significant, the economic burden was 17% less than the other countries, due to Thailand’s universal health insurance system.

Lee JS, Mogasale, V, Lim JK et al. 2017. A multi-country study of the economic burden of dengue fever: Vietnam, Thailand, and Colombia. PLoS NTD. 11(10).

Episodes of dengue can cause catastrophic health costs for households

In a 2002 study from Cambodia, households with a dengue patient had to borrow money at high interest rates and lose productive assets (land) to repay debts linked to healthcare costs. Public healthcare cost significantly less than private healthcare but was either not present where people lived or did not have a good reputation.

Van Damme, W., Van Leemput, L., Por, I., et al. 2004. Out-of-pocket health expenditure in poor households: evidence from Cambodia. Tropical Medicine and International Health. 9(2).