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Knowledge Hub

Influenza vaccination during pregnancy reduces severe pneumonia rates in infants, especially during peak influenza circulation

An analysis of data from three studies showed that the rates of severe pneumonia in infants in their first six months of life was 20% lower overall in infants whose mothers received the influenza vaccination during pregnancy than in infants whose mothers had not, and the rates of severe pneumonia was 56% lower during periods when influenza circulation was highest. These findings correspond with evidence that influenza infection predisposes individuals to pneumococcal infection.

The incidence rate of severe pneumonia in the vaccine group compared to the control group was 43% lower in South Africa, 31% lower in Nepal, but not significantly different in Mali.

Full Citation:
Omer SB, Clark DR, Aqil AR et al.. 2018. Maternal influenza immunization and prevention of severe clinical pneumonia in young infants: Analysis of randomized controlled trials conducted in Nepal, Mali and South Africa. Pediatric Infectious Disease Journal. 37(5).

Title of Article: Maternal influenza immunization and prevention of severe clinical pneumonia in young infants: Analysis of randomized controlled trials conducted in Nepal, Mali and South Africa

Author(s): Omer SB, Clark DR, Aqil AR et al.

Publication Year: 2018

Publication Name: Pediatric Infectious Disease Journal

Publication Volume: 37(5)

Publication Source URL: https://www.ncbi.nlm.nih.gov/pubmed/29443825

DOI (Digital Object Identifier): 10.1097/INF.0000000000001914

Topics: Health

Disease Vaccines: Influenza | Pneumonia

Countries: Mali | Nepal | South Africa

WHO Regions: Africa | South-East Asia