This 2013 review summarizes data from several randomized trials in which measles and tuberculosis vaccines were associated with a substantial reduction in overall child mortality, which cannot be solely explained by prevention of the target disease. These studies suggest that in addition to disease-specific effects, some live vaccines may also provide “nonspecific effects” that enhance the immune system’s ability to protect against additional pathogens.
Full Citation:
Benn CS, Netea MG, Selin LK et al.. 2013. A small jab – a big effect: Nonspecific immunomodulation by vaccines. Trends in Immunology. 34(9).
Title of Article: A small jab – a big effect: Nonspecific immunomodulation by vaccines
Author(s): Benn CS, Netea MG, Selin LK et al.
Publication Year: 2013
Publication Name: Trends in Immunology
Publication Volume: 34(9)
Publication Source URL: https://pubmed.ncbi.nlm.nih.gov/23680130/
DOI (Digital Object Identifier): 10.1016/j.it.2013.04.004
Topics: Health
Disease Vaccines: Measles | Tuberculosis/BCG
Immunization Terms: Non-specific effects | Review article
Countries: Guinea-Bissau
WHO Regions: Africa