The Knowledge Hub

What is the Knowledge Hub?

Explore the VoICE Knowledge Hub—a searchable database featuring the latest peer-reviewed research on immunization benefits, especially in low- and middle-income countries. Browse the Knowledge Hub using a variety of different filters to find vaccine evidence based on country, region, topic, or disease. Click on a tag to find more evidence on a specific area, such as the return on investment of vaccines or impacts of infectious disease outbreaks.


Diseases & Vaccines


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Immunization Terms

Immunization can help overcome barriers to healthcare access and reduce high rates of TB in Inuit populations

Native populations experience barriers to health care access such as limited knowledge, stigma, community social isolation, and geographic isolation. As a result, Inuit populations in Canada suffer 300 times higher rates of TB than the Canadian-born non-Indigenous population.

. 2018. CPHO Spotlight on Eliminating Tuberculosis in Canada. Public Health Agency of Canada. .

Immunization is important for recent migrants to overcome health barriers and prevent diseases like tuberculosis

Recent migrants face barriers to accessing health care including language and cultural barriers, limited knowledge, food and housing insecurity, stress, and lack of resources available during prolonged travel. In Canada, though foreign-born populations make up only 22% of the total population, 70% of active tuberculosis cases occurred in this population.

. 2018. CPHO Spotlight on Eliminating Tuberculosis in Canada. Public Health Agency of Canada. .

Immunocompromised people are particularly vulnerable to IPD

In a long-term study of Canadian surveillance data researchers found that immunocompromised people were at a 12-fold risk of invasive pneumococcal disease (IPD) compared to healthy people. In addition, the risk of death from IPD in immunocompromised people was found to be 30-80% higher than healthy individuals who had contracted IPD. 10 years after introduction of PCV7 in Canada, the incidence of IPD due to serotypes included in the vaccine had decreased by 90%.

Shigayeva, A., Rudnick, W., Green, K., et al. 2016. Invasive pneumococcal disease among immunocompromised persons: implications for vaccination programs. Clinical Infectious Disease. 62(2).