The Knowledge Hub

What is the Knowledge Hub?

Explore the VoICE Knowledge Hub—a searchable database featuring the latest peer-reviewed research on immunization benefits, especially in low- and middle-income countries. Browse the Knowledge Hub using a variety of different filters to find vaccine evidence based on country, region, topic, or disease. Click on a tag to find more evidence on a specific area, such as the return on investment of vaccines or impacts of infectious disease outbreaks.


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Immunization campaigns provide more equitable access to childhood vaccinations compared to maternal health services

An analysis of survey data in Latin America and Caribbean countries found that DPT3 coverage rates among indigenous children were significantly lower than in children of European or mixed ethnicity in three out of 14 countries, while significant inequities between these groups in coverage of maternal health services, such as antenatal care and delivery by a skilled birth attendant, existed in most of the countries. The greater equity in access to childhood vaccination by ethnic group may be because vaccinations are often delivered in the communities through immunization campaigns, whereas maternal health services require accessing health facilities, which may incur user fees and transportation costs.

Mesenburg MA, Restrepo-Mendez MC, Amigo H et al.. 2018. Ethnic group inequalities in coverage with reproductive, maternal and child health interventions: cross-sectional analyses of national surveys in 16 Latin America and Caribbean countries. Lancet Global Health. 6(8).

Immunization can help reduce the risk of stunting caused by diarrhea in children

A pooled analysis of nine studies assessing the effects of diarrhea on stunting prior to the age of 24 months showed that the odds of stunting were significantly increased with each diarrheal episode. Each day of diarrhea prior to attaining 24 months of age also contributed to the risk of stunting. For each five episodes of diarrhea, the odds of stunting increased by 13%. In addition, once a child becomes stunted, only 6% of those stunted at 6 months of age recovered by 24 months of age.

Checkley, W., Buckley, G., Gilman, R.H., et al.. 2008. Multi-country analysis of the effects of diarrhoea on childhood stunting. International Journal of Epidemiology. 37(4).

Cholera outbreaks can cause millions of dollars in economic impacts

A study of a cholera outbreak in Peru in 1991-92 estimates that the national economy conservatively suffered more than US$50 million in economic losses due to reduced tourism revenue, reduced revenue on export of goods and lower domestic consumption as a result of the outbreak of cholera.

Suarez, R. and Bradford, B.. 1993. The economic impact of the cholera epidemic in Peru: An application of the cost of illness methodology. Office of Health, Bureau for Research and Development, Water and Sanitation for Health (WASH) Project. Field Report. 415.

Rotavirus vaccine introduction positively impacted coverage and timing of other vaccines

An analysis of rotavirus vaccine introduction in two Latin American countries (Honduras and Peru) suggests that the introduction of the vaccine might have had a favorable impact on coverage and timing of other similarly scheduled vaccinations.

Schweitzer, A., Pessler, F. and Akmatov, M.K.. 2016. Impact of rotavirus vaccination on coverage and timing of pentavalent vaccination – experience from two Latin American countries. Human Vaccines & Immunotherapeutics. 12(5).