What is the Knowledge Hub?
Explore the VoICE Knowledge Hub—a searchable database featuring the latest peer-reviewed research on immunization benefits, especially in low- and middle-income countries. Browse the Knowledge Hub using a variety of different filters to find vaccine evidence based on country, region, topic, or disease. Click on a tag to find more evidence on a specific area, such as the return on investment of vaccines or impacts of infectious disease outbreaks.
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Rotavirus vaccination reduces the risk of childhood seizures by 20-34% in the US and Spain
Seizures are the most common non-gastrointestinal symptom associated with rotavirus infection. Studies have found that rotavirus vaccination significantly reduced the risk of childhood seizures during the year following vaccination by approximately 20% for seizures requiring emergency care or hospitalization in the US and by 16-34% for childhood seizures requiring hospitalization in Spain.
Rivero-Calle I, Gomez-Rial J, Martinon-Torres F. 2016. Systemic features of rotavirus infection. Journal of Infection. 72.
Immunization with PCV7 and PCV13 in Madrid reduced pneumococcal disease and antibiotic resistance
Following the introduction of PCV7 and later PCV13 in Madrid, Spain, there was a 70% reduction in the incidence of invasive pneumococcal disease in children less than 15 years of age. There was also a pronounced decline in the percentages of penicillin- and cefotaxime-resistant strains of the pneumococcus bacteria. After PCV13 was introduced in 2010, cefotaxime resistance among meningitis patients completely disappeared and both cefotaxime and penicillin resistance among non-meningitis cases declined to very low levels (<3%).
Picazo JJ, Ruiz-Contreras J, Casado-Flores J et al.. 2019. Impact of 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in children under 15 years old in Madrid, Spain, 2007 to 2016: the HERACLES clinical surveillance study. Vaccine. 37(16).
Rotavirus vaccination reduces the risk of childhood seizures requiring emergency care or hospitalization
Seizures are the most common non-gastrointestinal symptom associated with rotavirus infection. Studies have found that during the year following rotavirus vaccination the risk of childhood seizures were reduced by 18-21% for seizures requiring emergency care or hospitalization in the U.S. and by 16-34% for childhood seizures requiring hospitalization in Spain.
Rivero-Calle I, Gomez-Rial J, Martinon-Torres F. 2016. Systemic features of rotavirus infection. Journal of Infection. 72.
Vaccinating all healthcare workers against Ebola could have dramatically reduced cases
Using data on the spread of Ebola from person to person during historical Ebola outbreaks to compare vaccination strategies, researchers found that prophylatically vaccinating all healthcare workers would have decreased the number of disease cases in the 2014 epidemics in Guinea and Nigeria by 60-80%.
Coltart CE, Johnson AM, Whitty CJ. 2015. Role of healthcare workers in early epidemic spread of Ebola: policy implications of prophylactic compared to reactive vaccination policy in outbreak prevention and control. BMC Medicine. 13(271).